Catechol-O-methyltransferase connects dopamine homeostasis to redox signaling, metal homeostasis, and protein folding in schizophrenia
It is demonstrated that loss of membrane-bound catechol-O-methyltransferase (MB-COMT), a key degrader of DA in the brain, disrupts cellular metal handling and redox-regulatory pathways and triggers widespread protein misfolding in schizophrenia and Parkinson’s disease.
S. Tripathi, Suwarna Chakraborty, Neil B. Wood et al.
· Proceedings of the National... · 0 citations