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Author

S. Tolaney

2 papers indexed here

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Review Open access Oct 2026

Expanding the therapeutic scope of PARP inhibitors in breast cancer: current indications and future directions

Homologous recombination repair deficiency (HRD) occurs in approximately 10% of breast tumors and represents a major targetable vulnerability across multiple cancer types. Impairment of the homologous recombination DNA repair pathway — arising through somatic and germline mutations in homologous recombination repair ge...

Charlotte S. Walmsley, Adela Rodríguez, P. Konstantinopoulos et al. · 0 citations
Open access Sep 2026

Tumor genomic landscape of older patients with metastatic breast cancer☆

Background Metastatic breast cancer (MBC) in older patients has distinct clinical and histologic characteristics. Elucidating the genomic basis of MBC helps identify potential therapeutic targets to improve outcomes for older patients with MBC. Patients and methods Using a prospective database and targeted DNA sequenci...

H. Gupta, K. Brantley, T. Grinda et al. · 0 citations

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