Author

S. Temple

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Open access Sep 2026

MAPT regulates autophagic-lysosomal function and phagocytosis in human microglia

Tauopathies are characterized by the accumulation and spread of pathogenic tau aggregates throughout the brain, a process that is increasingly recognized to involve not only neurons but also microglia. However, whether pathogenic MAPT directly alters microglial degradative capacity remains poorly understood. Here, usin...

Kylie J. Schache, Rui Zhang, Audrey Street et al. · bioRxiv · 0 citations

Open access Sep 2026

Large-scale single-molecule analysis of tau proteoforms

Proteins exist as diverse proteoforms resulting from a combination of genetic variation, alternative splicing and post-translational modifications. Current methods struggle to capture this complexity at the single-molecule level. Here we introduce Iterative Mapping of proteoforms, a method that enables massively parall...

James Joly, V. Budamagunta, Zheng-Jian Zhang et al. · Nature Methods · 1 citation