Bone microarchitecture and microfractures in disorganized bone in a young female with pycnodysostosis and atypical femur fractures: A case for novel fracture prediction technology using ALIGNOGRAM1.0 analysis.
It is demonstrated how disorganization may act as a causative mechanism as an independent biomarker of fragility in patients with PYCD and quantifying bone disorganization on standard radiographs may provide complementary information beyond conventional assessments of bone mass and structure.