Author

S. Steigerwald

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Open access Oct 2026

SPARCS enables scalable recovery of complex image-based phenotypes for genetic screening.

Forward genetic screening links genotype to phenotype by introducing random genetic perturbations and identifying phenotype-altering mutations. Although genome-scale screens are routine for simple phenotypes in cultured cells, extending them to complex image-based phenotypes remains challenging. Here, we present spatia...

Niklas A. Schmacke, Sophia C. Mädler, G. Wallmann et al. · Cell · 0 citations

#protein folding Open access Aug 2026

In the same cell, the proteome defines cellular state and the transcriptome marks transitions

A scalable technology is introduced that quantifies thousands of proteins and transcripts in the same cell, separating RNA from protein by tip-based C18 capture and pairing full-length RNA sequencing with latest-generation mass spectrometry to yield deep proteome and transcriptome from the same cells.

M. Thielert, Enes Ugur, Maximilian Zwiebel et al. · bioRxiv · 1 citation