Background: Recurrent implantation failure (RIF) remains one of the most challenging presentations in assisted reproductive technology and is characterized by failure to achieve clinical pregnancy despite the transfer of multiple good-quality embryos. Advances in embryo selection and preimplantation genetic testing hav...
Athanasios Zikopoulos, Efthalia Moustakli, A. Potiris et al.· Journal of Clinical Medicine· 0 citations
Endocrine disorders and inherent flaws in oocyte quality are traditional causes of female infertility. Increasing research indicates that structural and biomechanical alterations in the ovarian microenvironment may significantly contribute to reproductive decline. Progressive extracellular matrix remodeling, stromal fi...
C. Voros, F. Chatzinikolaou, G. Papadimas et al.· Current Issues in Molecular...· 0 citations
Regulated cell death (RCD) has emerged as a fundamental determinant of cellular homeostasis and tissue remodeling, extending far beyond the classical concept of apoptosis. The identification of emerging RCD pathways, including ferroptosis, pyroptosis, necroptosis, cuproptosis, PANoptosis, and autophagy-dependent cell d...
S. Stavros, Efthalia Moustakli, N. Kathopoulis et al.· Cells· 0 citations
Overall, current evidence supports exosome-mediated communication as a biologically relevant mechanism across reproductive physiology, infertility-related disorders, and HPV-associated disease, while further standardized and clinically validated studies are required to establish their diagnostic and therapeutic utility...
Serafoula-Natalia Siourtou, S. Stavros, M. Daskalaki et al.· Current Issues in Molecular...· 0 citations
Recurrent pregnancy loss (RPL), a multifactorial condition in reproductive medicine, affects approximately 1–3% of couples. Increasing evidence implicates endometrial dysfunction, immune dysregulation, impaired angiogenesis, and oxidative stress (OS) in its pathophysiology, highlighting the need for biologically target...
S. Stavros, A. Potiris, M. Daskalaki et al.· Medical Science· 0 citations
Understanding how endocrine dysregulation interacts with metabolic, genomic, and epigenetic alterations and changes in the follicular microenvironment may facilitate the identification of biomarkers and the development of targeted approaches to preserve oocyte quality during reproductive aging.
Maria Fotara, Efthalia Moustakli, M. Daskalaki et al.· Current Issues in Molecular...· 0 citations
Clinical data do not support a widespread protective effect of maternal Se status against adverse neonatal outcomes, and the existing body of evidence is heavily constrained by moderate to very low quality, driven by small sample sizes, insufficient confounding adjustments, and suboptimal exposure assessment timing at...
Nikolina Stachika, E. Tsarna, Eleni Solomou et al.· Journal of Clinical Medicine· 0 citations
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