Multi-complex pharmacophore mapping for the repurposing of FDA drugs as HTLV-1 protease inhibitors: Toward novel anti-HTLV-1 therapeutics.
Human T-cell Leukemia Virus Type 1 (HTLV-1) protease (PR) is a critical enzyme involved in viral maturation and represents a key target for the development of antiviral therapeutics. Despite significant efforts to design novel inhibitors, many candidates have failed due to poor pharmacokinetic and safety profiles. In t...