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Open access Sep 2026

Network-integrated Virtual Screening Identifies HIF-1α Targeting Phytochemicals from Ajuga decumbens

Background: Tumour hypoxia is a critical hallmark of cancer progression, contributing to metastasis, therapeutic resistance, and poor clinical outcomes. Hypoxia-inducible factor-1 alpha (HIF-1α) regulates cellular adaptation to hypoxia by modulating angiogenesis, metabolism, and survival. Targeting HIF-1α represents a...

P. Tej, K. Nitya, S. Sundar et al. · 0 citations
Sep 2026

A decade of dysplasia: clinicopathological patterns and malignant transformation with Candida co-infection.

BACKGROUND Oral epithelial dysplasia (OED) is a key precursor to oral squamous cell carcinoma (OSCC); however, predicting its malignant transformation remains a clinical challenge due to its multifactorial aetiology and regional variations in risk-related habits. This study aimed to analyse the clinicopathological char...

D. Radhakrishnan, S. Selvam, Deepak Pandiar · 0 citations
Open access Sep 2026

Functional network analysis of Hodgkin Lymphoma identifies critical regulatory nodes in cancer-associated pathway

Hodgkin Lymphoma (HL) is a haematological malignancy characterized by the abnormal proliferation of malignant B lymphocytes within an inflammatory microenvironment. Despite advances in therapeutic strategies, a subset of patients continues to experience relapse or treatment resistance, highlighting the need for improve...

S. Ankitha, Nitya Krishnasamy, S. Selvam et al. · 0 citations

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