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Review Sep 2026

Novel Targets and Treatments for Neurodegenerative Diseases Revealed by Drosophila.

Neurodegenerative disorders (NDDs) such as Alzheimer's disease, Parkinson's disease, and others lack any disease-modifying therapy due to the lack of mechanistic understanding of the disease etiology. The genetic tractability, short lifespan, and conserved cellular biology of Drosophila melanogaster have positioned the...

Pablo Reina-Gonzalez, Aiesha Anchan, Jennifer Bekos et al. · 0 citations
Open access May 2024

Genetic screening and metabolomics identify glial adenosine metabolism as a therapeutic target in Parkinson’s disease

Neuronal α-synucleinopathies, including Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), lack disease-modifying therapies. We developed a Drosophila model for identifying novel glial-based therapeutic targets for α-synucleinopathies. In this model, human α-synuclein is expressed in neurons and individual g...

MJ Sodders, J. Ávila-Pacheco, EC Okorie et al. · 1 citation

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