Author

S. Sandur

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Review Open access Oct 2026

Spatiotemporal Redox Regulation of Cell-Cycle Progression: Dynamic Functions of Cellular Redox Regulatory Proteins

Highlights What are the main findings? Redox regulation is dynamically coordinated with cell-cycle progression through phase-specific changes in H2O2 generation, sensing, buffering, and resolution. MnSOD, peroxiredoxins, Nrf2/HO-1/NQO1, glutathione, glutaredoxins, GPXs, and the thioredoxin system perform complementary...

R. Patwardhan, S. Morjaria, G. Nandi et al. · Cells · 0 citations

Aug 2026

Mitocurcumin disrupts glutathione balance by modulating Klf9/GSR axis to overcome platinum resistance in non-small cell lung cancer and restores immune surveillance in cold tumor.

Chemoresistance remains a major barrier in non-small cell lung cancer (NSCLC) therapy. Glutathione reductase (GSR), a central regulator of glutathione redox homeostasis, has been implicated in tumor survival, yet its role in non-small cell lung cancer (NSCLC) chemoresistance remains unclear. We demonstrated that GSR is...

G. Panigrahi, Khushboo A Gandhi, Amisha Joshi et al. · Free Radical Biology & Medic... · 0 citations

Sep 2026

Peroxiredoxin 6 Silencing Remodels Lipid Metabolism and Redox Pathways to Promote Ferroptosis-Mediated Radiosensitization in Nonsmall Cell Lung Cancer

Ionizing radiation (IR) induces oxidative stress and lipid peroxidation with ferroptosis contributing to radiation-induced cancer cell death. Peroxiredoxin 6 (PRDX6), a multifunctional enzyme involved in phospholipid repair and redox regulation, has been implicated in ferroptosis regulation, but its role in the radio...

Debojyoti Pal, R. Patwardhan, S. Sandur · Journal of Proteome Research · 0 citations