Author

S. Roudi

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Open access Sep 2026

Enhancing the efficacy of siRNA Antibody Oligonucleotide Conjugates (AOCs) through chemical design

Antibody-oligonucleotide conjugates (AOCs) offer a promising solution to delivery challenges of therapeutic oligonucleotides. However, the relationship between their complex chemical architectures and biological activity remains poorly understood, limiting the development of important structure-function relationships....

O. Hayes, J. Rädler, E. Filipiak et al. · bioRxiv · 0 citations

Open access Sep 2026

Lipid–ASO therapeutics exhibit differential tissue targeted delivery upon systemic or local CNS administration

It is demonstrated that lipid identity critically determines ASO efficacy, productive cellular uptake, and regional CNS engagement, emphasizing the need for context-specific lipid design in ASO therapeutic development.

S. Roudi, H. Y. Estupiñán, O. Saher et al. · bioRxiv · 0 citations

Aug 2026

Efficient genome editing in the non-human primate brain using programmable extracellular vesicles

It is shown that an optimized single-guide RNA scaffold architecture improves RNP stability, and when combined with additional EV engineering leads to a three-hundred-fold increase in potency, enabling efficient base editing or knockout in primary cells, human brain organoids and in vivo, including the mouse brain.

Xiuming Liang, Houze Zhou, Z. Nizamudeen et al. · bioRxiv · 0 citations