Author

S. Rooijakkers

2 papers indexed here

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Review Open access Aug 2026

Complement-dependent phagocytosis in the clearance of various cellular targets.

Phagocytosis is the process of recognition and uptake of cells or large cellular debris; this process contributes to the removal of pathogens, cancerous cells and dead cells from the human body. Phagocytosis is greatly enhanced by the deposition of opsonins on the target cells, which act as a bridge between the target...

M. Blanter, Max L. B. Grönloh, P. E. Marques et al. · Protein & Cell · 0 citations

Open access Sep 2026

Identification of a C3b-specific nanobody that does not bind C3 and blocks alternative pathway convertases

C3b-specific nanobodies are developed by generating phage libraries from llamas immunized with purified and surface-bound C3b and Functionally, UNbC3b-1 inhibits complement activity in the alternative pathway (AP), likely by preventing association between substrate C3 and the AP C3 convertase (C3bBb).

Eva M. Struijf, B. Bardoel, Joanne E. van Keulen et al. · bioRxiv · 0 citations