Simplexviruses of non-human primates differ in their capacity to cause severe disease in humans. Papiine alphaherpesvirus 2 (PaHV-2) of baboons has not been reported to be pathogenic in humans while human infection with macacine alphaherpesvirus 1 (McHV-1, Herpes B Virus) can cause fatal disease. In order to study PaHV...
The successive emergence of SARS-CoV-2 variants with altered tissue tropism has progressively decoupled transmissibility from lower respiratory tract pathogenicity. Omicron lineages transmit exceptionally well whilst limiting severe lung disease. Here, we demonstrate that this phenotype has evolved through two temporal...
A. Aggarwal, S. Ognenovska, Timothy Ison et al.· bioRxiv· 0 citations
Using pseudovirus particles, it is shown that subclade K-HA drives augmented entry into certain cell lines and displays significant antibody evasion, suggesting that current vaccines may provide considerable protection.
Nicole Moor, N. Chen, G. Behrens et al.· npj Vaccines· 0 citations
It is proposed that there is somatic hypermutation of existing B cell clones rather than de novo generation from naive B cells in JN.1-adapted booster vaccines and this finding indicates maturation of pre-existing, class-switched MBC rather than substantial de novo recruitment of naïve B cells.
M. Stankov, Matthias Bruhn, M. Hoffmann et al.· Nature Communications· 0 citations
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