Author

S. Petridi

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Open access Sep 2026

mRNA-LNP therapy restores systemic nucleoside imbalance in a mitochondrial DNA depletion syndrome

Mitochondrial DNA depletion syndromes (MDS) are inherited conditions caused by pathogenic variants in mitochondrial DNA maintenance genes. Most MDS are severe, fatal and incurable conditions. Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an MDS resulting from loss-of-function mutations in the TYMP ge...

Nissa L. Carrodus, Jenny J. Yang, Javier Ramón et al. · bioRxiv · 0 citations

Open access Aug 2026

Nup153 regulates neuronal responsiveness through HDAC1-mediated epigenetic modulation

Neural activity-dependent gene regulation is central to the development of neural networks and neuronal plasticity. Induction of activity-dependent gene programs is equally important as repression of these programs, and both need to be balanced carefully. However, little is known about how repressive mechanisms modulat...

Abhinav Soni, S. Petridi, Maria Ludovica Sforza et al. · bioRxiv · 0 citations