S. Parajuli

Clinical spectrum and burden of extrahepatic manifestations in chronic hepatitis B

Chronic hepatitis B virus (HBV) infection is associated with both hepatic and extrahepatic complications. While liver-related outcomes are well characterized, the burden, demographic patterns, and survival associated with extrahepatic manifestations (EHMs) remain incompletely defined. This study aimed to evaluate the s...

Efficacy of Buccal Midazolam in the Management of Acute Convulsion

Clinical outcomes associated with GLP-1 receptor agonist use in metabolic dysfunction–associated steatohepatitis

Metabolic dysfunction–associated steatohepatitis (MASH) is an important progressive liver disorder that can lead to hepatic decompensation, hepatocellular carcinoma (HCC), and premature death. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have demonstrated beneficial effects on metabolic dysfunction and liver h...

Diagnostic accuracy of neutrophil-to-lymphocyte ratio compared to C-reactive protein for neonatal sepsis: Evidence from Birat Medical College Teaching Hospital

Background: Clinical manifestations of neonatal sepsis are non-specific, and no single biomarker consistently diagnoses all cases. The neutrophil-to-lymphocyte count ratio (NLCR) is an accessible marker in adults, but its diagnostic efficacy in neonates remains understudied. Aims and Objectives: The aim of this study w...