Author

S. Palumbo

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Open access Sep 2026

Age-Associated YBX1 Phosphorylation Regulates the Keratinocyte Senescence-Associated Secretory Phenotype Through Translational Control

Skin aging is characterized by epidermal atrophy, reduced keratinocyte proliferation, and the accumulation of senescent cells that sustain a chronic, low-grade inflammatory secretome known as the senescence-associated secretory phenotype (SASP). We previously showed that Y-box binding protein 1 (YBX1) limits keratinocy...

Valdi Ven Japranata, Michelle Liu, F. Boncimino et al. · Cells · 0 citations

Open access Sep 2026

p63 and p73 drive cutaneous squamous cell carcinoma through convergent transcriptional control of EGFR signaling.

Aberrant transcriptional regulation is central to squamous cell carcinoma (SCC), but how related lineage transcription factors coordinate oncogenic programs is poorly understood. We show that TP73, together with TP63, is upregulated in skin SCC and is required for tumorigenesis. Using chromatin profiling, transcriptomi...

D. Antonini, M. Ferniani, S. Palumbo et al. · Cell Reports · 0 citations