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Author

S. Ouellette

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Open access Mar 2026

Coordinated topoisomerase function shapes the fluoroquinolone response of Chlamydia trachomatis

DNA supercoiling is essential for the developmental cycle of Chlamydia trachomatis, yet its role in shaping antibiotic responses remains poorly understood. We investigated how the fluoroquinolone moxifloxacin (Mox) influenced C. trachomatis growth across developmental stages with its distinct supercoiling levels. Early...

Andrew Terrebonne, Caitlynn Diggs, S. Ouellette et al. · 0 citations
Open access Aug 2026

Coordinated topoisomerase function shapes the fluoroquinolone response of Chlamydia trachomatis

It is demonstrated that Mox exerts differential effects across the developmental stages and that disrupted gyrase-TopA coordination drives chlamydial developmental arrest and a noncanonical, DNA replication-limited persistent phenotype.

Andrew Terrebonne, Caitlynn Diggs, S. Ouellette et al. · 0 citations

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