S. Oki

Coincidence of L1 retrotransposition and DNA repair deficiency elicits synthetic lethality in S-phase mature neurons

Summary Neurodegeneration involves the entangled processes of cell-autonomous and non-cell-autonomous neuronal cell death, which leads to a collapse in the integrity of the neural network and causes behavioral symptoms. Here, we demonstrate that aberrant cell cycle re-entry (CCR) is prominent in mature neurons and that...