Author

S. Ogino

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Open access Sep 2026

RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation

The RNF43 p.G659fs (RNF43659mut) mutation occurs in 8% of colorectal cancers (CRCs) and is enriched in microsatellite instability–high (MSI-H) tumors. Although RNF43659mut promotes tumor growth through phosphatidylinositol 3-kinase/protein kinase B/mechanistic target of rapamycin (PI3K/AKT/mTOR) activation independent...

Pushpamali De Silva, Samantha Fitzgerald, Jules Cazaubiel et al. · Science Advances · 0 citations

Open access Sep 2026

Tumor microbial biodiversity and microsatellite instability in colorectal cancer

Background Growing evidence links the gut microbiome to colorectal cancer (CRC) progression, with certain bacterial species enriched in specific molecular tumor subtypes. DNA mismatch repair deficiency in CRC, evidenced by the presence of microsatellite instability (MSI), has been consistently associated with a favorab...

Calen Mendall, Meredith A. J. Hullar, Keith R. Curtis et al. · PLoS ONE · 0 citations