Author

S. O’Brien-Gortner

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Jul 2026

Abstract B027: CRISPR screens identify thioredoxin reductase 1 as a target for inducing disulfidptosis in IDH1 -mutant glioma models

It is shown that glioma models are dependent on TXNRD1 for survival, but acquire adaptive antioxidant changes to survive TXNRD1 loss, and the underlying mechanism using thioredoxin reductase 1 (TrxR1) inhibitors and TXNRD1 knockout (KO) models is validated.

S. O’Brien-Gortner, Dinar Rani K, D. Conole et al. · Clinical Cancer Research · 0 citations