Author

S. Nsobya

3 papers indexed here

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Open access Sep 2026

Multiple local PfDHFR I164L haplotype expansions drive Plasmodium falciparum antifolate resistance in Uganda

Mutations in the Plasmodium falciparum genes, pfdhfr and pfdhps, drive antifolate resistance and threaten malaria control in regions where sulfadoxine-pyrimethamine (SP) is the primary chemoprevention strategy. The spatial patterns and evolutionary dynamics of these mutations in high-transmission settings remain incomp...

V. Asua, K. Niaré, Shreeya Garg et al. · Nature Communications · 1 citation

Open access Sep 2026

PfPHAST: Plasmodium falciparum Public Health Amplicon Sequencing Tool, a Streamlined Panel for Malaria Genomic Surveillance

Genomic tools can support malaria control policy through surveillance of Plasmodium falciparum populations, tracking antimalarial drug resistance, pfhrp2/3 deletions that compromise rapid diagnostic tests, and selection at the circumsporozoite protein (PfCSP) vaccine target, as well as through molecular correction of t...

Francis D. Semakuba, B. Nsengimaana, Monica Mbabazi et al. · bioRxiv · 0 citations

Open access Aug 2026

Emergence and spread of Plasmodium falciparum PX1 polymorphisms associated with decreased susceptibility to antimalarials in Uganda

Artemisinin-based combination therapies are the cornerstone of malaria treatment and control. In Africa, artemether–lumefantrine is the most widely used first-line artemisinin-based combination therapy, but its efficacy in Uganda is increasingly threatened by the emergence of artemisinin partial resistance and reduced...

K. Niaré, Bersabeh Tafesse, Mayland Treat et al. · Nature Medicine · 2 citations