Author

S. Nanjappa

3 papers indexed here

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Open access Sep 2026

Semaglutide and pioglitazone restore airway mucosal homeostasis by resolving Pseudomonas aeruginosa pyocyanin-induced mucus hypersecretion, ciliostasis, and type 2 airway inflammation

Rationale Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. As lung transplantation is the only curative option and current therapies are largely based on managing clinical symptoms, novel treatments are urgently needed. Objective Previously, we showed that the first-generation...

Cong Wu, Nitish A. Kulkarni, Shi Qian Lew et al. · Frontiers in Immunology · 0 citations

Open access Jul 2026

Oxphos, not Glycolysis, Promotes the Survival Of Effector Tc17 Cells 2307301

IL-17A+ T cells are implicated in immunity and immunopathology. Fungal infections primarily occur in immunocompromised hosts. We have previously shown that experimental fungal vaccine-induced Tc17 cells are stable, durable, and necessary for sterilizing immunity in CD4+ T cell deficiency. Metabolism is pliable bu...

Reni John, S. Nanjappa · Journal of Immunology · 0 citations

Open access Jul 2026

Yeast antigens source modulates vaccine potency and immunity mediated by CD8+ T cells in CD4+ T cell-deficient hosts 2305523

Given the global rise in fungal infections, which primarily occur in hosts with CD4+ T cell deficiency or dysfunction, and the lack of FDA-approved vaccines, it is imperative to develop novel vaccine platforms. Our previous studies indisputably showed that an attenuated fungal strain vaccine bestowed sterilizing...

Nagabhushan Chandrashekar, S. Nanjappa · Journal of Immunology · 0 citations