Open access
Aug 2026
Translocon Remodeling Modulates Ribosomal Frameshifting and the Maturation of the Sindbis Virus Structural Polyprotein
The results indicate that −1PRF and spike protein maturation in alphaviruses is tuned by the dynamic remodeling of the ER translocon, which could allow polyprotein biogenesis to adapt to different stages of viral replication and to distinct host or vector environments.
Antonio Bonifasi, Gayani Apsara Ranasinghe, Ashish Jhangiani et al.
· bioRxiv · 0 citations