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S. Mukherjee

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Open access Sep 2026

Topologically complex knotted proteins are processed differentially by ATP‐dependent proteases ClpXP and ClpAP

Knotted proteins can present a distinct topological and mechanical challenge to the AAA+ cellular degradation machineries, determined by the relative size of the knot and the pore dimensions of these enzymes. In this study, we investigated the degradation mechanism of knotted proteins of different topological complexit...

S. Mukherjee, Hema Chandra Kotamarthi · 0 citations

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