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Open access Sep 2026

CDKPredict: a clinicogenomic model for risk-adapted therapeutic intervention in breast cancer

Abstract Wide variation in outcomes is observed for patients with hormone-receptor-positive metastatic breast cancer (MBC) receiving first-line CDK4/6 inhibitors plus endocrine therapy (CDK4/6i+ET). Although front-line escalation strategies are beginning to enter clinical practice, assigning patients to intensified or...

Luca Boscolo Bielo, F. Sánchez-Vega, Subhiksha Nandakumar et al. · 0 citations
Aug 2026

Pathologic Complete Response (pCR) Rate and Predictors of Response to Taxane, Trastuzumab, and Pertuzumab in HER2‑Positive Breast Cancer: Secondary Analyses of EA1181/CompassHER2 pCR.

PURPOSE EA1181 (ClinicalTrials.gov identifier: NCT04266249) is a single-arm trial evaluating neoadjuvant taxane, trastuzumab, and pertuzumab (THP) in patients with clinical stage II/IIIa human epidermal growth factor receptor 2 (HER2)-positive breast cancer. This report focuses on the secondary end points of pathologic...

N. Tung, Feng-Min Zhao, A. DeMichele et al. · 1 citation

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