The brain was long been regarded as an immune-privileged organ with a lack of lymphatic drainage, partly because of the absence of parenchymal lymphatic vessels. This long-held doctrine has been challenged by recent advancements in central lymphatic vascular biology. The central drainage network, which consists of the...
Shixin Ding, Ji-Guang Yang, Ze Wang et al.· Translational Neurodegenerat...· 0 citations
Summary Background Single-cell and single-nucleus RNA sequencing have transformed our understanding of human skeletal muscle biology, yet reproducibility and cross-study comparison remain limited by the lack of a unified reference framework and consistent cell-type annotation. Methods We systematically searched for scR...
C. Nelke, F. Babilon, C. Schroeter et al.· EBioMedicine· 0 citations
The findings support a prominent role of EBV-specific cellular immunity in ongoing MS pathophysiology and suggest that reduced EBV-reactive T-cell responses may contribute to this potency.
Jakob Stögbauer, S. Bronder, Niklas Saenz Kämpfer et al.· Journal of Neuroinflammation· 0 citations
Acute kidney injury (AKI) affects approximately 15% of all hospitalized individuals and nearly half of those admitted to intensive care units and is increasingly recognized as a systemic syndrome whose consequences extend well beyond structural and functional changes confined to the kidney. Experimental studies highlig...
Benedetta Manca, L. Forni, Hendrik Booke et al.· Critical Care· 0 citations
The findings suggest that neuroaxonal and astrocytic stress is a component of adolescent psychopathology, particularly in AN, and sNfL appears sensitive to starvation-related neurobiological changes, with levels normalizing alongside weight restoration.
Marc Pawlitzki, L. Masanneck, L. Schlarbaum et al.· Translational Psychiatry· 0 citations
This review addresses measurement methods (SiMoA, automated platforms), pre-analytics/matrix effects, and central confounders (esp. age, BMI/volume of distribution, renal function, intercurrent events), emphasizing standardization via age- and BMI-corrected reference data using Z-scores or percentiles.
Hernan Inojosa, K. Akgün, L. Masanneck et al.· Fortschritte der Neurologie...· 0 citations
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