Author

S. Majumdar

2 papers indexed here

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Open access Oct 2026

Distinct activation mechanisms underlie ligand efficacy at a GPCR

Ligands that bind to the same G protein-coupled receptor (GPCR) can produce widely different levels of signaling. These differences in efficacy are central to pharmacology, yet how a receptor sequence determines signaling level remains incompletely understood. Here we develop a deep mutational pharmacology approach to...

Matthew K. Howard, Eve J. Fine, Karthik Srinivasan et al. · bioRxiv · 0 citations

Open access Sep 2026

Molecular determinants of ligand recognition and efficacy in the TRPM3 voltage sensor-like domain

Transient receptor potential melastatin 3 (TRPM3) is a calcium-permeable ion channel implicated in chronic pain and developmental and epileptic encephalopathies. The voltage sensor-like domain (VSLD) is a major site of pharmacological modulation, but the molecular determinants of ligand recognition and efficacy remain...

Vikram Dalal, V. Rangari, Samuel Eriksson Lidbrink et al. · bioRxiv · 0 citations