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Open access Oct 2026

Hepatocyte Serine Palmitoyltransferase 3 is essential for mitochondrial ceramide homeostasis and electron transport chain function.

Sphingolipids constitute essential membrane lipids that also function as signaling molecules mediating fundamental cellular processes. Disruption of constitutive sphingolipid metabolism contributes to a range of metabolic diseases. Sphingolipid biosynthesis is initiated by serine palmitoyltransferase (SPT), a heteromer...

Maryam Jamil, Anna Kovilakath, Yolander A. Valentine et al. · 0 citations
Open access Sep 2026

Catestatin peptide ameliorates tauopathy and amyloidogenesis via adrenergic inhibition.

Catestatin (CST), a CgA-derived peptide, is investigated for its role in modulating tauopathy and marked reductions in CST levels and an increase in Pancreastatin (PST) in the hippocampus and cortex of AD brains, as well as in the frontal cortex of CBD and the basal ganglia of PSP.

Suborno Jati, Satadeepa Kal, Daniel Muñoz-Mayorga et al. · 0 citations
Open access Sep 2026

Regulation of hepatic mitochondrial function by AIBP mitigates MASLD development.

Findings identify AIBP as a critical regulator of hepatic mitochondrial function and lipid metabolism and support AIBP as a potential therapeutic target for preventing the progression of MASLD to MASH.

Soo-Ho Choi, Subham Sharma, Seunghwan Choi et al. · 0 citations

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