Suzetrigine Versus Tramadol for Acute Postoperative Pain: Systematic Review and Meta-Analysis
Opioids remain the backbone for postoperative analgesia, but adverse effects and misuse remain major concerns. Suzetrigine (VX-548), a selective NaV1.8 inhibitor, is an FDA-approved non-opioid analgesic for moderate-to-severe acute pain. This PRISMA-guided systematic review and meta-analysis evaluated the efficacy and...