Highlights What are the main findings? T-cell–specific deletion of PTPN23 causes a marked reduction in T-cells, accompanied by preferential accumulation of TCRγδ T-cells and enrichment of differentiated effector/memory T-cell subsets. Multi-omics and single-cell RNA sequencing reveal alterations in T-cell developmental...
Rocio Sanchez Alvarez, M. Determann, L. Linzmeier et al.· Cells· 0 citations
Protein tyrosine phosphatases (PTPs) are key regulators of intracellular signaling cascades involved in cell growth, proliferation, differentiation, inflammation, and cancer. PTPN23, a non-receptor PTP, is involved in endosomal sorting and thereby regulates the internalization of growth factor receptors, such as the ep...
Rocio Sanchez Alvarez, C. Gottier, A. Montalban-Arques et al.· International Journal of Mol...· 0 citations
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