S. Kundu

A discrete-to-continuous mathematical model for ensemble distributions of a ligand-interacting macromolecular species across milieux-dependent conformational states may offer insights into the genesis and progression of cooperative binding

Small molecule modifiers whence bound, allosterically, will alter the binding of a macromolecule to one- or more-cognate substrates/partners via conformational and non-conformational changes. Although allostery is inferred directly from empirical data, the mathematical basis of these models, constraints deployed and ch...