The gut microbiome is known to modulate metabolic health, yet its role in coronary heart disease (CHD) and heart failure with preserved ejection fraction (HFpEF) remains unclear. In the present study, we profiled the gut microbiome of 234 participants using shotgun metagenomic sequencing across controls (n = 43), indiv...
A. Tauekelova, N. Katkenov, S. Kozhakhmetov et al.· Frontiers in Microbiology· 0 citations
The gut microbiome has been proposed as a contributor to Alzheimer’s disease (AD) pathogenesis via the microbiota–gut–brain axis, but findings across cohorts are inconsistent and scarce data exist from Central Asian populations. We used shotgun metagenomic sequencing to compare the gut microbiome of AD patients and cog...
A. Issilbayeva, S. Kozhakhmetov, A. Kushugulova et al.· International Journal of Mol...· 0 citations
Despite some recent declines, suicides remain a major public health issue in Kazakhstan, with rates persistently above global benchmarks. This study provides the first integrated characterization of temporal trends, demographic characteristics, and regional distribution of suicide mortality in Kazakhstan.
Th...
A. Kossumov, T. Zhakupova, N. Imambayeva et al.· Frontiers in Public Health· 0 citations
The cervicovaginal virome remains poorly characterized in relation to human papillomavirus (HPV) infection and bacterial community structure. We performed shotgun metagenomic sequencing of 311 cervicovaginal specimens from a Kazakhstani cohort spanning seven groups defined by HPV status and cervical cytology. Viral com...
A. Kushugulova, N. Kamzayeva, S. Kozhakhmetov et al.· Viruses· 0 citations
The gut eukaryome, comprising the protists and fungi that fall within the strict definition of the microbiota together with the macroscopic helminths and arthropods that lie outside it, is under-detected by clinical microscopy and by short-read 16S/18S sequencing, yet is increasingly implicated in inflammatory and au...
Ruslan Kalendar, A. Daniyarov, Ulykbek Kairov et al.· Frontiers in Microbiology· 0 citations
Introduction The cervicovaginal microbiome is a key determinant of reproductive health. Its multi-kingdom structure and ecological interactions remain insufficiently characterized across diverse populations. This study aimed to define the composition and cross-kingdom dynamics of the cervical microbiome in women withou...
A. Rakhmankulova, S. Kozhakhmetov, A. Kovenskiy et al.· Frontiers in Microbiology· 0 citations
Current evidence suggests that functional gut microbiome dysregulation may represent a more reproducible biological feature of MDD than isolated taxonomic alterations alone, and large-scale longitudinal multi-omics studies using standardized methodologies are required.
Gulshat Dalibayeva, M. Goremykina, S. Kozhakhmetov et al.· Epidemiologia· 0 citations
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