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Oct 2026

Clinical impact of prospective circulating tumour DNA testing for minimal residual disease in colorectal cancer: the INTERCEPT programme experience.

BACKGROUND The impact of circulating tumour DNA (ctDNA) detection, which informs minimal residual disease (MRD) after curative treatment, remains debated especially for stage IV patients. OBJECTIVE The study objectives were to evaluate the prognostic role of MRD and to estimate lead time (LT) at different timepoints...

G. Maddalena, K. Aziz, Ryan Sun et al. · 0 citations
Open access Sep 2026

A Pilot Head-to-Head Comparison of Two Bisulfite Conversion Kits for NGS-Based DNA Methylation Analysis of Liquid Biopsy Samples from Colorectal Cancer

Given the important role of early detection in improving cancer outcomes, epigenetic alterations, particularly DNA methylation, have emerged as powerful biomarkers for cancer screening and diagnosis. However, methylation profiling of cfDNA (circulating free DNA) presents particular technical challenges because cfDNA is...

Omayma Mazouji, A. Ouhajjou, R. Incitti et al. · 0 citations

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