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Author

S. Kleinstein

2 papers indexed here

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Open access Sep 2026

Transcriptomic characterization of transitional B cells reveals four subsets with perturbed activation profiles in scleroderma

Summary We previously demonstrated that patients with scleroderma or systemic sclerosis (SSc) have elevated autoreactive transitional B cells, including against topoisomerase I (anti-topoisomerase I autoantibody [ATA+]). This suggests that defective transitional B cell tolerance could drive autoimmunity in SSc. To inve...

Claire F. Beesley, Nina R. Goldman, Gisela Gabernet et al. · 0 citations
Open access Aug 2026

An Open Benchmark for Systems Vaccinology: Insights from the CMI-PB Challenges

Pre-existing antigen-specific antibody titers and baseline monocyte frequencies are identified as the most consistent predictors of post-vaccination immunity, highlighting the dominant role of individual immune setpoints.

Pramod Shinde, Lisa Willemsen, Jiyeun Lee et al. · 0 citations

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