Dual therapy with tofacitinib and steroids for acute severe ulcerative colitis: a randomized double-blind placebo-controlled trial.
BACKGROUND One-third of patients with acute severe ulcerative colitis (ASUC) fail intravenous corticosteroids. We evaluated whether adding tofacitinib to corticosteroids reduces treatment failure in ASUC. METHODS In this single-center, double-blind, placebo-controlled trial, adults with ASUC were randomized 1:1 to to...