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A reversible, growth factor-driven CAF program is defined and signaling mechanisms that may provide opportunities to selectively modulate tumor-supportive fibroblast states are identified.
Recent evidence suggests that TMEM106B expression is reduced in the brains of patients with Parkinson's disease (PD). However, an association between rare genetic variants in TMEM106B and PD risk has not been previously established. In this work, we investigated the association between rare TMEM106B variants and PD ris...
Rare variants in dystonia-related genes are not major contributors to overall PD risk, and signals observed in the EOPD subset require replication in larger cohorts.
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