S. Kaech

Chronic type II interferon promotes tumor growth through mitochondrial RNA-induced type I interferon and prostaglandin synthesis

Interferons are pro-inflammatory cytokines that promote immune cell engagement to eliminate malignant cells. Paradoxically, chronic interferon signaling can also activate anti-inflammatory mechanisms that allow cancer cells to evade the immune system. Here, we sought to determine the cellular mechanisms underlying this...

Radiation therapy synergizes with mRNA vaccination to overcome microglia-mediated suppression of dendritic cell migration and T cell priming in glioblastoma

Aging-induced hepatocyte CD44 drives IL6/STAT3 signaling that associates with impaired function of neighboring T cells

Liver cancer incidences increase dramatically beyond 55 years of age, suggesting that age-associated changes contribute critically to tumor initiation. However, the mechanisms linking liver aging and cancer initiation remain incompletely defined. This study investigated the role of CD44, a marker of liver tumor-ini...

Reprogramming of Glioblastoma-Immune Crosstalk to Overcome Immunotherapy Failure 2258791

A targetable molecular axis linking the bromodomain-containing protein 2 (BRD2) complex to fibronectin-driven immune suppression in mesenchymal-like GBM niches is identified, offering a promising combinatorial therapeutic strategy.