Author

S. K. Ramadan

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Open access Jul 2026

Design, synthesis, biological assessment, and integrated computational analysis of new pyrazole-based antimicrobial candidates

These findings highlight pyrazole-based scaffolds as promising antimicrobial candidates with favorable biological profiles, providing a strong basis for further structural optimization.

E. El-Helw, Selwan Hamed, A. El-ziaty et al. · Scientific Reports · 1 citation

#protein folding Aug 2026

Benzo[h]quinoline-based heterocyclic derivatives as Culex pipiens larvicidal candidates: synthesis, bioactivity, biochemical response, and in silico mechanistic insights.

Biochemical evaluation of triazinone 3 revealed significant reductions in acetylcholinesterase activity and in total protein, carbohydrate, and lipid contents compared with untreated larvae, indicating that larval mortality was accompanied by cholinergic disturbance and depletion of metabolic reserves.

E. El-Helw, Mahmoud Kamal, Eslam M. Hosni et al. · Bioorganic chemistry (Print) · 0 citations