S. J. Kalita

CuI-catalyzed cascade cyclization using indole-3-carbaldehydes and amidines for the synthesis of pyrimido[4,5-b]indoles.

We report a copper-catalyzed cascade cyclization for the concise synthesis of pyrimido[4,5-b]indole skeletons via direct C-H functionalization and concomitant C-N bond formation. This methodology utilizes an inexpensive catalytic system (CuI/2,2'-bipyridine). The reaction demonstrates remarkable functional group tolera...

Asymmetric counteranion-directed Lewis acid catalysis for the reaction of N,O-aminals via intractable iminium ion intermediates

Fluorinated 4-Methylideneisoxazolidin-5-ones: Synthesis and Apoptosis-Inducing Antiproliferative Activity

Sesquiterpene lactones, featuring an α-methylene-γ-lactone moiety, serve as lead compounds for anticancer drug development. Their nitrogen-containing analogues, namely, 4-methylideneisoxazolidin-5-ones, have attracted special attention for their promising anticancer properties. Installing a fluorine atom at the exocy...