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Open access Oct 2026

A reciprocally masked anti-CD47/IL-2 fusion protein promotes antitumor immunity and limits systemic toxicity.

Cancer immunotherapies have achieved meaningful clinical benefit but remain limited by systemic toxicities that restrict the use of potent immune modulators. CD47-targeting antibodies promote tumor cell phagocytosis but are hindered by hematologic toxicity, while IL-2 activates cytotoxic lymphocytes but induces broad,...

Elise Léchine, Laura Cons, L. Garnier et al. · 0 citations
Open access Aug 2026

Store-operated calcium signaling modulators improve a dendritic cell-based vaccine against melanoma

ABSTRACT Dendritic cells (DCs) are crucial for eliciting cytotoxic CD8+ T cell responses against intracellular pathogens, viruses, and cancer. DC-based vaccines can stimulate both cytotoxic and humoral immunity, as well as memory against cancer. However, efficacy has remained low, leaving room for improvement. Our prev...

Maria Cruz Cobo, L. Garnier, Marion Mandavit et al. · 0 citations

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