Open access
Jul 2026
Computationally engineered cyclic peptides reduce prion levels in vitro
These results establish a mechanistic link between peptide-induced stabilization of PrPc and inhibition of prion propagation and provide a generalizable framework for designing conformational stabilizers of aggregation-prone proteins.
Elpiniki Paspali, C. Morales, Daria De Raffele et al.
· bioRxiv · 0 citations