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Open access Aug 2026

A generalized approach for estimating the Pace of Aging

A weighted Pace of Aging framework is developed using data from the Swedish Adoption/Twin Study of Aging, a longitudinal cohort of older adults with up to nine waves of biomarker data collected over three decades, and is particularly well-suited for aging cohorts and in settings where marker relevance is uncertain a pr...

Marije H. Sluiskes, J. Deelen, H. Putter et al. · 0 citations
Open access Sep 2026

Integrative prediction of Alzheimer's disease and related dementias using multi‐omics aging clocks and genetic data

Abstract INTRODUCTION We tested whether combining Alzheimer's disease and related dementias (ADRD) polygenic risk scores (PRS) with biological aging markers improves ADRD risk prediction. METHODS In 16,215 UK Biobank (UKB) participants free of ADRD at baseline (median follow‐up: 10.08 years), 397 incident diagnoses wer...

S. Mostafaei, Karolina Gustavsson, Hampus Hagelin et al. · 0 citations

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