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S. Hadrup

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Open access Oct 2026

A pro-inflammatory effector-memory T cell program links peripheral EBV priming to CNS autoimmunity

T and B cell–mediated immunosurveillance of the central nervous system (CNS) can become maladaptive in multiple sclerosis (MS). Epstein–Barr virus (EBV) is a likely driver of MS, yet how exactly EBV-specific T cells contribute remains unclear. We generated an antigen-resolved atlas of blood and cerebrospinal fluid (CSF...

N. Kristensen, T. Tsaktanis, S. Frischholz et al. · 0 citations
Open access Sep 2026

Specificity-driven protein binder design with Odin-Multi

Odin-Multi is presented, a binder design framework that optimises a shared binder sequence against several complexes simultaneously, applying attractive objectives to on-targets and repulsive objectives to off-targets, and widens the range of binding behaviours accessible to computational design.

Valentas Brasas, C. R. Christensen, Kasper H. Björnsson et al. · 0 citations
Open access Jul 2026

Hybrid quantum-classical de novo design of MHC-binding peptides

Deep generative models have become a leading approach for designing therapeutic molecules, yet efficiently exploring vast biomolecular sequence spaces remains difficult, particularly for targets with limited training data. The prior distribution that seeds a generative model shapes which regions of sequence space it ex...

E. S. Engdal, Jonathan Funk, O. Bacarreza et al. · 0 citations

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