T and B cell–mediated immunosurveillance of the central nervous system (CNS) can become maladaptive in multiple sclerosis (MS). Epstein–Barr virus (EBV) is a likely driver of MS, yet how exactly EBV-specific T cells contribute remains unclear. We generated an antigen-resolved atlas of blood and cerebrospinal fluid (CSF...
N. Kristensen, T. Tsaktanis, S. Frischholz et al.· bioRxiv· 0 citations
Odin-Multi is presented, a binder design framework that optimises a shared binder sequence against several complexes simultaneously, applying attractive objectives to on-targets and repulsive objectives to off-targets, and widens the range of binding behaviours accessible to computational design.
Valentas Brasas, C. R. Christensen, Kasper H. Björnsson et al.· bioRxiv· 0 citations
Deep generative models have become a leading approach for designing therapeutic molecules, yet efficiently exploring vast biomolecular sequence spaces remains difficult, particularly for targets with limited training data. The prior distribution that seeds a generative model shapes which regions of sequence space it ex...
E. S. Engdal, Jonathan Funk, O. Bacarreza et al.· bioRxiv· 0 citations
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