AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
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Findings identify MYC-driven transcription as a therapeutic vulnerability in CIC -rearranged sarcoma and support combined CDK2 and CDK9 inhibition as a promising treatment strategy.
Very rare cells often have outsized physiologic functions. However, their low abundance presents a technical challenge for studying their function. Here, we generate a murine model, which enables the profiling of secreted proteomes (secretomes) from physiologically relevant low-abundance cells in complex tissues, witho...
The role of 2-hydroxyglutarate in lipid metabolism is currently unknown. Here we show that 2HG redistributes the partitioning of fatty acids into triglyceride storage and away from membrane phospholipid synthesis, mitochondrial oxidation, and lipotoxic intermediates. In primary human cardiac and vascular cells, both en...
The cyclin E-cyclin-dependent kinase 2 (CDK2) complex is a component of mammalian cell-cycle machinery that drives cell division. Hyperactivation of cyclin E-CDK2 is frequent in human cancers. Small-molecule CDK2 inhibitors are tested in clinical trials for cancer patients. Here, we report that cyclin E-CDK2 has a cell...
Recruitment to the cytokinetic ring (CR) requires its PxIxIT- and LxVP-binding surfaces and is mediated by multivalent interactions with the CR components paxillin-like Pxl1 and the F-BAR protein Cdc15, which reveals that CN targets a broad network of structural and signaling components involved in cell division.
The pathways that activate and inactivate Mga2 are defined, an evolutionary connection between the yeast lipid homeostasis regulator Mga2 and p53 is uncovered, and an evolutionary connection between the yeast lipid homeostasis regulator Mga2 and p53 is uncovered.
Combined genome-wide CRISPR knockout screening with base editor tiling screens at amino acid resolution reveal molecular rules governing HUWE1 phospho-degron recognition and identify a regulatory gate controlling substrate engagement and illustrate a generalizable strategy for resolving degradation mechanisms of undrug...
KinoPlex, a computational framework that integrates predicted protein structures and kinase recognition motifs to assign phosphorylation potential and kinase specificity to all serine/threonine/tyrosine residues, is presented.
Improvements enabling quantification of site-specific modifications, including post-translational modifications and covalent compound-protein interactions spanning diverse pathways are described.
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