Author

S. Gygi

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Jul 2026

An AI-enabled structural atlas decodes kinase specificity across the human proteome.

KinoPlex, a computational framework that integrates predicted protein structures and kinase recognition motifs to assign phosphorylation potential and kinase specificity to all serine/threonine/tyrosine residues, is presented.

David Vanderwall, Edward L. Huttlin, J. Mintseris et al. · Nature Biotechnology · 0 citations

#protein folding Open access Aug 2026

Next-generation multiplexed targeted proteomics quantifies post-translational modifications in disease and compound-protein interactions with high throughput

Improvements enabling quantification of site-specific modifications, including post-translational modifications and covalent compound-protein interactions spanning diverse pathways are described.

Steven R. Shuken, Geordon A. Frere, Charlotte R. Beard et al. · Nature Communications · 0 citations