Author

S. Giatrellis

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Open access Sep 2026

Highly resolved tumor architecture via matched spatial and nucleus transcriptomics from a single tissue section

Spatial transcriptomics often relies on reference-based deconvolution to infer cell types in a tissue context; however, public single-cell datasets can miss patient-specific biology. Here we introduce SIMPlex, a method that generates matched spatial and single-nucleus gene-expression profiles from the same 5 µm FFPE se...

Marcos Tito Machado, Meng-Xiao He, L. A. Galicia et al. · bioRxiv · 0 citations

Open access Apr 2026

Resolving cell lineages and gene functions in the developing mouse gastrointestinal tract using in utero transduction

In utero lentiviral transduction is established as an efficient approach to resolve clonal lineages and address gene functions in defined gut cell types and reveals fundamental principles of multi-lineage organogenesis and provides a framework to dissect the contribution of developmental programs to visceral dysfunctio...

Zi-Wei Liu, Krishnanand Padmanabhan, Jing-Yan He et al. · bioRxiv · 0 citations