Author

S. Galdiero

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Open access Sep 2026

A Thiophilic Metal-Mediated Cysteine S‑Detritylation Strategy: Enhancing Orthogonality in Solid-Phase Peptide Synthesis

The selective manipulation of cysteine residues in solid-phase peptide synthesis (SPPS), beyond disulfide bridge formation, remains challenging, and an efficient protocol for the selective removal of the widely used trityl (Trt) protecting group under solid-phase conditions has yet to be established. To overcome this l...

Salvatore Mottola, R. Bellavita, I. Boccino et al. · ACS Omega · 0 citations

Open access Aug 2026

Lipid anchor engineering controls cell-penetrating arginine-rich peptide presentation for efficient siEGFR liposomal delivery to triple-negative breast cancer cells

The optimized nanocarrier promoted efficient uptake of fluorescent siRNA in MDA-MB-231 cells and achieved functional delivery of anti-EGFR, leading to substantially reduced expression of the target gene at both transcript and protein levels.

P. Białecki, S. Braccia, T. Makowski et al. · bioRxiv · 0 citations