S. G. Grant

836. Chronic oral administration of sertraline, alprazolam, or quetiapine modifies the excitatory synaptome architecture in mice

Abstract Background Excitatory synapses are highly diverse, differing in their proteome composition, nanoscale organization, and protein turnover. This enables the classification of synapses into types and subtypes, each with a distinct spatial distribution, thus creating the synaptome architecture. Synapse dysfunction...

Dynamic structural plasticity facilitates the developmental assembly of cochlear inner hair cell ribbon synapses

Sound detection occurs in the cochlea, where sensory inner hair cells (IHC) accurately convert auditory stimuli into neurochemical signals. Presynaptically, IHCs harbor synaptic ribbons, specialized scaffolds that facilitate ultrafast and indefatigable exocytosis. During synapse assembly and subsequent maturation, IHC...

Stage-specific proteomic signatures of synaptopathy in Alzheimer’s disease

Large-scale dimensional behavioral profiling dissociates fear memory from locomotor confounds in mice: The necessity of baseline-normalized metrics

It is shown that baseline locomotor normalization is essential for interpreting fear conditioning as a memory assay and provide an open framework for selecting and reporting locomotor-normalized metrics.