Persistent activation of dermal fibroblasts drives progressive skin fibrosis in systemic sclerosis (SSc), a connective tissue disease. However, the mechanisms sustaining fibroblast activation remain incompletely defined. Interleukin-33 (IL-33), an alarmin-like IL-1 family cytokine, signals via the membrane receptor ST2...
Miyuki Hayashi, K. Makino, M. Ide et al.· Journal of dermatology (Prin...· 0 citations
Effective activation of cancer-reactive T cells by antigen-presenting cells (APCs) is essential for tumor elimination. However, dendritic cell (DC)-based cancer vaccines often yield inconsistent clinical outcomes due to patient-dependent variability. We established IL-12-producing proliferative myeloid cells (IL12-pMCs...
Masateru Yamamoto, Rong Zhang, T. Kobayashi et al.· Molecular Therapy· 0 citations
Aging skin is characterized by wrinkles, loss of elasticity, and impaired barrier function, largely driven by alterations in dermal fibroblasts and extracellular matrix remodeling. Chronic, age-related inflammation, called inflammaging, is a central activity underlying these changes. Immunoglobulin G (IgG) has recently...
Takehisa Suzuki, Haruki Horiguchi, Shuji Yamamura et al.· Journal of Investigative Der...· 0 citations
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