Author

S. Fleishman

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Open access Sep 2026

Computational design of optimized and preferentially paired human TCR constant regions for improved T cell function

T cell receptor (TCR) gene transfer is a promising approach for cancer immunotherapy, but its efficacy is limited by mispairing of TCR chains, which reduces surface expression and may generate off-target specificities. We applied the PROSS and FuncLib algorithms to engineer human TCR constant regions for improved stabi...

Maria Radman, Astar Shamul-Raybi, Jake Parker et al. · Science Advances · 0 citations

Open access Jul 2026

Combining Stability-Centered Atomistic Design with Machine Learning for Targeted Enzyme Optimization

A machine-learning-assisted enzyme-engineering (MLEE) workflow that adds substrate-specific functional information to htFuncLib through an initial screening and sequencing round that may bypass the need for transition-state models and reduce the effort required for obtaining high-activity variants.

Li Wan, Mahdi Bagherpoor Helabad, Lena Fraedrich et al. · bioRxiv · 0 citations