Long-term nourishment with quercetin, a naturally occurring plant flavonoid abundant in citrus fruits, buckwheat, and onions, has been associated with reduced risks of chronic diseases, including cancer. In this study, we evaluated the therapeutic potential and the anti-cancer properties of quercetin in lung cancer usi...
Christine Carvalho, Elvedina Nendel, Susanne Mittler et al.· Cell Death Discovery· 0 citations
The data indicate that the tumor microenvironment induces Blimp-1 in immunosuppressive Treg and CD8+ T effector cells, thereby limiting the therapeutic efficacy of anti-tumor immune responses.
S. Finotto, M. Chiriac, Susanne Krammer et al.· Journal of Immunology· 0 citations
Chimeric antigen receptor (CAR) T cell therapy in solid tumors is limited by the immunosuppressive tumor microenvironment (TME). Since we have identified T-bet as a strong anti-tumor candidate, we thought to explore new therapies against NSCLC by developing next-generation CAR T cells and patient-derived lung can...
Lin Li, D. Trufa, Bastian Zinkel et al.· Journal of Immunology· 0 citations
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